PRP vs Growth Factors vs Exosomes

An image that details the progression from PRP to growth factors to exosomes for regenerative aesthetics

Regenerative aesthetics has evolved from PRP to growth factors to exosomes, today’s best in class for professional use regenerative aesthetics topicals. This is how they compare. 

About PRP

Platelet-Rich Plasma (PRP) was groundbreaking regenerative aesthetics technology in the 1970s. PRP requires a blood draw that requires blood handing protocols, processing, and produces variable regenerative strength due to factors like the patient’s health status, age, and lifestyle.

The concentration and quality of growth factors in PRP depend entirely on the person’s own platelets, which leads to inconsistent outcomes. How long the blood was centrifuged and what may or may not have been added creates more inconsistency.

About Growth Factors

In 2012, AnteAGE Growth Factor Solution was a regenerative aesthetics game changer. This professional-grade product contains lab-cultured bone marrow mesenchymal stem cell growth factors and cytokines in precise, standardized concentrations. 

Unlike PRP, which only contains growth factors from platelets, AnteAGE Growth Factor Solution provides a broader spectrum of regenerative proteins specifically selected for their skin rejuvenating properties. 

A hand holding AnteAGE Growth Factor Solution vials at Rejuvience Med Spa Scottsdale

AnteAGE Growth Factor Solution is produced in a USA-based controlled laboratory environment, ensuring purity and optimal concentration for regenerative aesthetic applications. 

The Growth Factor Solution delivers consistent results across treatments without the blood draw or the blood handling risks. It was the gold standard until exosomes.

BENEV ERC exosome box with the exosome and hyaluronic acid dilutant vials in front of the box at Rejuvience Med Spa Scottsdale

And Then There Were Exosomes

Exosomes are a small, fluid-filled sac or blister that is formed by a membrane, typically found within cells where it functions to transport substances

Exosomes, discovered in 1983, are small fluid-filled membrane sacs that contain “cargo” of growth factors, proteins, and nucleic acids and other bioactive compounds that support cellular renewal and tissue regeneration. 

What makes exosomes so powerful is that they deliver their regenerative ‘cargo’ by fusing with skin cell membranes to release their contents directly into the cell’s cytoplasm.

Although exosomes were discovered more than 30 years ago, it wasn’t until sometime around 2010 that their regenerative properties began receiving attention. Then there were technical challenges with mass production. It took roughly another 10 years to produce purified exosomes product that were pure and could be freeze-dried into a powder so that it could remain stable in storage.

BENEV Exosome Regenerative Complex was one of the first to market with AnteAGE MDX Exosome products joining the exosome line up in 2023. 

PRP vs Growth Factors vs Exosomes

While all three approaches promote skin regeneration, the evolution from PRP to growth factors to exosomes represents progressively more refined and targeted skin rejuvenation solutions. 

Growth Factor and Exosome products eliminate the variability, inconvenience, and blood handling risk associated with PRP while providing more consistent, controlled delivery of regenerative compounds. 

Rejuvience Med Spa Scottdale integrates these professional use products into our regenerative aesthetics treatment protocols, including Procell Microchanneling, Tixel Skin Resurfacing, and Exceed Medical Microneedling procedures to achieve optimal treatment outcomes.

Complimentary Skincare at Consultation Rejuvience Med Spa Scottsdale

Not sure which mix of treatments and/or products is best for your concerns? Book a complimentary consultation.

There’s no cost, and there’s no obligation. During your appointment we’ll discuss your concerns and treatment options. 

We understand we are not the right fit for everyone, and we do refer out when we think a different specialist will be of more help.